Statins: antimicrobial resistance breakers or makers?
نویسندگان
چکیده
منابع مشابه
Statins: antimicrobial resistance breakers or makers?
INTRODUCTION The repurposing of non-antibiotic drugs as adjuvant antibiotics may help break antimicrobial resistance (AMR). Statins are commonly prescribed worldwide to lower cholesterol. They also possess qualities of AMR "breakers", namely direct antibacterial activity, synergism with antibiotics, and ability to stimulate the host immune system. However, statins' role as AMR breakers may be l...
متن کاملTa-AgNps are potential antimicrobial resistance breakers
An easy and rapid microwave-assisted green synthesis of silver nanoparticles (AgNPs) was carried out using aqueous bark extract of arjuna and their antibacterial and anti-biofilm potential was investigated. The AgNPs were characterized by various techniques .The FTIR data revealed the presence of plant organic constituents and metabolites bound to TA-AgNPs, which contributes for their stability...
متن کاملReplicative helicase loaders: ring breakers and ring makers
Helicase loaders transfer the ring-shaped replicative helicases onto DNA. They assort into two classes: ring breakers, which place stabile hexameric rings on DNA via transient gaps at subunit interfaces; and helicase makers, which assemble hexameric rings around DNA from monomeric helicase units.
متن کاملCholesterol suppresses antimicrobial effect of statins
Objective(s):Isoprenoid biosynthesis is a key metabolic pathway to produce a wide variety of biomolecules such as cholesterol and carotenoids, which target cell membranes. On the other hand, it has been reported that statins known as inhibitors of isoprenoid biosynthesis and cholesterol lowering agents, may have a direct antimicrobial effect on the some bacteria. The exact action of statins in ...
متن کاملUnexpected antimicrobial effect of statins.
OBJECTIVES Epidemiological studies of statins have suggested a link between statin therapy and a decreased risk of sepsis. It has been proposed that the mechanism underlying this apparent protective effect of statins relates to their known immunomodulatory and anti-inflammatory effects. The aim of this study was to explore the antimicrobial effect of statins. METHODS Simvastatin (Merck) and f...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PeerJ
سال: 2017
ISSN: 2167-8359
DOI: 10.7717/peerj.3952